The proper understanding of such a complex system requires quantification. Fortunately, immunologists nowadays generate large, quantitative, and temporal data sets on the development of immune responses, the maintenance of memory, the lymphocyte repertoire, and the sequence evolution of the pathogens. The interpretation of these large data sets requires both bioinformatics and modeling (i.e., Systems Immunology). The Utrecht Center for Quantitative Immunology (UCQI) brings together an experienced collaborative team of immunologists, bioinformaticians, and mathematical modelers. Having worked together on quantitative immunology for more than a decade, we have learned to speak each others language, which enables fruitful iterations between our experiments and computational analysis of the immunological data generated by these experiments using modeling and bioinformatics.
We have expertise in bioinformatics, with a long history in the data-driven peptide MHC prediction tools. These tools are used to predict immune responses, study viral evolution, and answer questions about the cross-reactivity of MHC molecules and T cell receptors. We have expertise in estimating the turnover rates of the cells, their migration rates, the rates at which individual cells form contacts with other cells, and the rates at which immune cells clear pathogens upon such a contact. As a team we perform experiments in mice and man, two photon microscopy, and develop bioinformatic tools, mathematical models, and computer simulations models.
One of our model pathogens is HIV-1, which is modifying the normal population dynamics in the immune system in such a way that the system slowly collapses, and for which an enormous amount of bioinformatic data is available.
This fall we organize an expert meeting on tissue resident memory cells in Amsterdam (Program).
For contact information please see the pages of the individual members.