Contact Information

Joost Beltman
Theoretical Biology
Utrecht University
Padualaan 8
3584 CH Utrecht
the Netherlands
email:


Research interests


As a Postdoc at Utrecht University (from 2008-2011 on a Veni grant) I investigated the dynamic nature of cell migration and cell-cell interactions as can nowadays be observed by in vivo imaging approaches. We developed novel approaches for the quantitative analysis of such dynamic imaging data as well as incorporating experimental data into computational cell migration models. Our questions were related to the functioning of our immune system, e.g., T cell migration, T cell-dendritic cell interactions, recruitment of T cells into the immune response, B cells migrating within germinal centers and the killing of target cells by cytotoxic T lymphocytes.

Currently I am working as a Senior Postdoc in the group of Ton Schumacher in the Immunology division of the Netherlands Cancer Institute (NKI). Apart from continuing my work on the modelling of T cell migration, I am studying next generation sequencing data of "barcoded" mice to determine lineage relationships between cells.


Publications


In the field of Immunology

Gerlach, C., Rohr, J.C., Periée, L., van Rooij, N., van Heijst, J.W.J., Velds, A., Urbanus, J., Naik, S.H., Jacobs, H., Beltman, J.B., de Boer, R.J. & Schumacher, T.N.M.
Heterogeneous Differentiation Patterns of Individual CD8+ T Cells.
Science (2013). Medline

Vroomans, R.M.A., Marée, A.F.M., de Boer, R.J. & Beltman, J.B.
Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens.
PLoS Computational Biology 8(11): e1002763(2012). DOI PDF Supporting Info Videos

Ariotti, S., Beltman, J.B., Chadaczek, G., Hoekstra, M.E., van Beek, A.E., Gomez-Eerland, R., Ritsma, L., van Rheenen, J., Marée, A.F.M., Zal, T., de Boer, R.J., Haanen, J.B.G. & Schumacher, T.N.
Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen.
Proceedings of the National Academy of Sciences USA 109(48): 1979-19744 (2012). DOI Medline PDF Supporting Info

Kvistborg, P., Shu, C.J., Heemskerk, B., Fankhauser, M., Thrue, C.A., Toebes, M., van Rooij, N., Linnemann, C., van Buuren, M.M., Urbanus, J.H., Beltman, J.B., Thor Straten, P., Li, Y.F., Robbins, P.F., Besser, M.J., Schachter, J., Kenter, G.G., Dudley, M.E., Rosenberg, S.A., Haanen, J.B., Hadrup, S.R. & Schumacher, T.N.
TIL therapy broadens the tumor-reactive CD8+ T cell compartment in melanoma patients.
OncoImmunology 1(4): 409-418 (2012). Medline PDF Supporting Info

Beltman, J.B., Allen, C.D.C., Cyster, J.G. & De Boer, R.J.
B cells within germinal centers migrate preferentially from dark to light zone.
Proceedings of the National Academy of Sciences USA 108: 8755-8760 (2011). DOI Medline PDF

Beltman, J.B., Marée, A.F.M. & De Boer, R.J.
Analysing immune cell migration.
Nature Reviews Immunology 9: 789-798 (2009). DOI Medline PDF Supporting Info

Beltman, J.B., Henrickson, S.E., von Andrian, U.H., De Boer, R.J. & Marée, A.F.M.
Towards estimating the true duration of dendritic cell interactions with T cells.
Journal of Immunological Methods: 347: 54-69 (2009). DOI Medline PDF Supporting Info Video

Beltman, J.B., Marée, A.F.M. & De Boer, R.J.
Spatial modelling of brief and long interactions between T cells and dendritic cells.
Immunology and Cell Biology 85: 306-314 (2007). Medline PDF Videos

Beltman, J.B., Marée, A.F.M., Lynch, J.N., Miller, M.J. & De Boer, R.J.
Lymph node topology dictates T cell migration behavior.
Journal of Experimental Medicine 204: 771-780 (2007). Medline PDF Supporting Info Videos

Borghans, J.A.M., Beltman, J.B. & De Boer, R.J.
MHC polymorphism under host-pathogen coevolution.
Immunogenetics 55: 732-739 (2004). PDF

Beltman, J.B., Borghans, J.A.M. & De Boer, R.J.
Major Histocompatibility Complex: Polymorphism from coevolution.
In Adaptive dynamics of infectious diseases (eds. Dieckmann, U., Metz, J.A.J., Sabelis, W. & Sigmund, K.) 210-221 (Cambridge Univ. Press, Cambridge, 2002). PDF


In the field of Evolution/Speciation

Beltman, J.B. & Metz, J.A.J.
Speciation: more likely through a genetic or through a learned habitat preference?
Proceedings of the Royal Society of London B 272: 1455-1463 (2005). PDF Appendix

Beltman, J.B. & Haccou, P.
Speciation through the learning of habitat features.
Theoretical Population Biology 67: 189-202 (2005). PDF

Beltman, J.B.
Evolution by learning: consequences of choosing like your mother.
PhD Thesis Leiden University (2004). PDF

Beltman, J.B., Haccou, P. & ten Cate, C.
Learning and colonization of new niches: a first step towards speciation.
Evolution 58: 35-46 (2004). PDF

Beltman, J.B., Haccou, P. & ten Cate, C.
The impact of learning foster species' song on the evolution of specialist avian brood parasitism.
Behavioral Ecology 16: 917-923 (2003). PDF