Personalia
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Research
MHC class I molecules play an important role in the onset of host cellular immune responses against intracellular pathogens. The genes of the MHC genomic region are among the most polymorphic in the human genome, giving rise to a plethora of MHC class I molecules with distinct peptide binding specificities.
We are interested in elucidating the impact of this binding specificity on host-pathogen interaction and infectious disease outcome. Further, my research focusses on comparing the peptide-binding repertoires of human MHC class I molecules with those of non-human primates in order to unravel what might have shaped the MHC peptide binding repertoires in these closely related species.
Education
| 2009 - present | Post doc at Utrecht University |
| 2006 - 2009 | PhD in Life Sciences (Immunogical Bioinformatics) |
| Center for Biological Sequence Analysis, Technical University of Denmark | |
| 2000 - 2006 | Diplom (Dipl.-Inf.) Bioinformatics, University of Tuebingen, Germany |
Publications
2012
Hoof I, van Baarle D, Hildebrand WH, Kesmir C. Proteome Sampling by the HLA Class I Antigen Processing Pathway. PLoS Comp Biol. Accepted for publication.
Sette A, Sidney J, Southwood S, Moore C, Berry J, Dow C, Bradley K, Hoof I, Lewis MG, Hildebrand WH, McMurtrey CP, Wilson NA, Watkins DI, Mothe BR. A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules. Immunogenetics. 2012 Feb 10. pubmed
2011
van Deutekom HW, Hoof I, Bontrop RE, Kesmir C. A Comparative Analysis of Viral Peptides Presented by Contemporary Human and Chimpanzee MHC Class I Molecules. J Immunol. 2011 Oct 31. pubmed
Rao X, Hoof I, Fontaine Costa AI, van Baarle D, Kesmir C. HLA class I allele promiscuity revisited. Immunogenetics. 2011 Jun 22. pubmed
Southwood S, Solomon C, Hoof I, Rudersdorf R, Sidney J, Peters B, Wahl A, Hawkins O, Hildebrand W, Mothe BR, Sette A. Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificities. Immunogenetics. 2011 Jan 28. pubmed
2010
Lundegaard C, Hoof I, Lund O, Nielsen M. State of the art and challenges in sequence based T-cell epitope prediction. Immunome Research 2010 Nov 3;6(Suppl 2):S3 (Review). pubmed
Larsen MV, Lelic A, Parsons R, Nielsen M, Hoof I, Lamberth K, Loeb MB, Buus S, Bramson J, Lund O. Identification of CD8+ T cell epitopes in the West Nile virus polyprotein by reverse-immunology using NetCTL. PLoS One. 2010 Sep 14;5(9):e12697. pubmed
Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothe BR. The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype. Immunogenetics. 2010 Jul;62(7):451-64. pubmed
Hoof I, Perez CL, Buggert M, Gustafsson RK, Nielsen M, Lund O, Karlsson AC. Interdisciplinary Analysis of HIV-Specific CD8+ T Cell Responses against Variant Epitopes Reveals Restricted TCR Promiscuity. J Immunol. 2010 May 1;184(9):5383-91. pubmed
Rapin N, Hoof I, Lund O, Nielsen M. The MHC motif viewer: a visualization tool for MHC binding motifs. Curr Protoc Immunol. 2010 Feb;Chapter 18:Unit 18.17. pubmed
Vita R, Zarebski L, Greenbaum JA, Emami H, Hoof I, Salimi N, Damle R, Sette A, Peters B. The Immune Epitope Database 2.0. Nucleic Acids Res. 2010 Jan;38(Database issue):D854-62. pubmed
2009
Weber T, Rausch C, Lopez P, Hoof I, Gaykova V, Huson DH, Wohlleben W. CLUSEAN: a computer-based framework for the automated analysis of bacterial secondary metabolite biosynthetic gene clusters. J Biotechnol. 2009 Mar 10;140(1-2):13-7 pubmed
Hoof I, Peters B, Sidney J, Pedersen LE, Sette A, Lund O, Buus S, Nielsen M. NetMHCpan, a method for MHC class I binding prediction beyond humans. Immunogenetics. 2009 Jan;61(1):1-13 pubmed
2008
Rapin N, Hoof I, Lund O, Nielsen M. MHC motif viewer. Immunogenetics. 2008 Dec;60(12):759-65 pubmed
Hoof I, Kesmir C, Lund O, Nielsen M. Humans with chimpanzee-like major histocompatibility complex-specificities control HIV-1 infection. AIDS. 2008 Jul 11;22(11):1299-303 pubmed
2007
Rausch C, Hoof I, Weber T, Wohlleben W, Huson DH. Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution. BMC Evol Biol. 2007 May 16;7:78 pubmed